Methotrexate has a number of uses. It is used in the treatment of the following cancers:- breast cancer- a number of cancers that arise during pregnancyIt is used in the palliative treatment of acute and subacute lymphocytic leukaemia.When used in combination with corticosteroids, Methotrexate can induce remission in acute lymphoblastic leukaemia, and is commonly used for maintenance of this remission.Methotrexate can also be used in the symptomatic treatment of severe, disabling psoriasis that has not been responsive to other therapies.It is also useful in the treatment of severe, recalcitrant, active rheumatoid arthritis that is not responsive to NSAIDs and other disease modifying drugs.